During exercise, total peripheral resistance (TPR) decreases because of the effect of

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[IX B 2]. During exercise, local metabolites accumulate in the exercising muscle and cause local vasodilation and decreased arteriolar resistance of the skeletal muscle. Because muscle mass is large, it contributes a large fraction of the total peripheral resistance (TPR). Therefore, the skeletal muscle vasodilation results in an overall decrease in TPR, even though there is sympathetic vasoconstriction in other vascular beds.

During Exercise, Total Peripheral Resistance (TPR) Decreases Because of the Effect