End-organ resistance to which of the following hormones results in polyuria and elevated serum osmolarity?

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[Chapter 5, VII C; Table 5.6]. End-organ resistance to antidiuretic hormone $(\mathrm{ADH})$ is called nephrogenic diabetes insipidus. It may be caused by lithium intoxication (which inhibits the $\mathrm{G}_{\mathrm{s}}$ protein in collecting duct cells) or by hypercalcemia (which inhibits adenylate cyclase). The result is inability to concentrate the urine, polyuria, and increased serum osmolarity (resulting from the loss of free water in the urine).

End-Organ Resistance to Which of the Following Hormones Results in Polyuria