Metabolism of both amide and ester-type local anesthetics may be compromised in patients with serious liver dysfunction.

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Both amide and ester-type local anesthetics are metabolized in the body, with amides primarily metabolized in the liver and esters hydrolyzed by plasma cholinesterase. Serious liver dysfunction can compromise the metabolism of amide local anesthetics due to reduced hepatic enzyme activity and potentially affect ester metabolism indirectly by altering plasma cholinesterase levels.

Metabolism of Both Amide and Ester-Type Local Anesthetics May Be