Bupivacaine's high pKa translates into a slow onset time, which explains why it is a long-acting anesthetic.

Name: Bupivacaine's high pKa translates into a slow onset time, which explains why it is a long-acting anesthetic.
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Quizplus · Accepted Answer

Bupivacaine's high pKa does translate into a slow onset time. This has nothing to do with bupivacaine's duration, however, which is related to the strength of its protein receptor binding in sodium ion channels.

Bupivacaine's High PKa Translates into a Slow Onset Time, Which