The correct pKa of lidocaine is:

Question

Quizplus · Accepted Answer

The pKa of lidocaine is approximately 7.9, but it is often rounded to 8.1 for simplicity in many references. However, the presence of epinephrine does not change the pKa of lidocaine itself; it is a property inherent to the chemical structure of lidocaine. The options provided seem to be misleading or incorrect, but the closest to the actual pKa value of lidocaine is option A, if we consider it a typographical error or simplification. Lidocaine's pKa suggests it is a weak base, and its efficacy as a local anesthetic can be influenced by the pH of the tissue it is injected into, but not by the addition of epinephrine.

The Correct PKa of Lidocaine Is