Approximately what percentage of the action of local anesthetic drugs is due to the membrane expansion theory?

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Quizplus · Accepted Answer

The membrane expansion theory accounts for approximately 10% of the action of local anesthetic drugs. This theory suggests that these drugs work by integrating into the lipid bilayer of neuronal membranes, causing them to expand and thereby affecting the function of membrane-bound proteins, including ion channels. However, the primary mechanism of action for local anesthetics is through direct interaction with and blockade of sodium channels, which is not explained by the membrane expansion theory.

Approximately What Percentage of the Action of Local Anesthetic Drugs