Without Using a Calculator or Computer, Determine Which of the Two

Without using a calculator or computer, determine which of the two numbers $2^{244}$ and $16 \cdot 10^{72}$ is larger.

A) $2^{244}$ is larger than $16 \cdot 10^{72}$
B) $16 \cdot 10^{72}$ is larger than $2^{244}$
C) They are equal to each other
D) Cannot be determined