What is the clearest statement of the nation-centered focus of the U.S. Constitution?

Name: What is the clearest statement of the nation-centered focus of the U.S. Constitution?
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The supremacy clause (Article VI, Clause 2) states that the Constitution and federal laws made under it are the supreme law of the land. This emphasizes the nation-centered focus of the Constitution, as it establishes the authority and power of the federal government over individual states.

What Is the Clearest Statement of the Nation-Centered Focus of the U.S