Drugs that are administered orally frequently travel first to the liver before entering the general circulation. This is referred to as:

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This phenomenon is known as first-pass metabolism or first-pass effect, where drugs are metabolized at a specific location in the body that results in a reduced concentration of the active drug upon reaching its site of action or systemic circulation. For orally administered drugs, this location is typically the liver.

Drugs That Are Administered Orally Frequently Travel First to the Liver