How Would You Expect a Disease of Cartilage Formation Affect

How would you expect a disease of cartilage formation affect bone development?

A) Cartilage is used for other tissues, not bone, so it will not affect bone development.
B) Cartilage defects will affect bone only via the effect on tendons and ligaments.
C) It would greatly disrupt bone development, since bones are originally formed of cartilage which becomes replaced.
D) The epiphysis is formed of cartilage so that will be disrupted, but otherwise the bone will be normal.