Your Research Project Involves the Characterization of a Recently Identified

Your research project involves the characterization of a recently identified transcription factor. As part of your project, you want to determine if this transcription factor binds directly to any of the general transcription factors. Unfortunately, however, you are having trouble expressing and purifying the full length protein. An option that may help you achieve your research goal would be to

A) abandon this experiment and try a vastly different approach to your question, since transcription domains cannot be separated.
B) express large amounts of the general transcription factors.
C) express and purify only the DNA-binding domain, since transcription domains can be separated.
D) try to express and purify only the activation domain, since transcription domains can be separated.