In humans, sickle-cell disease is due to a defect in a single gene and is inherited in an autosomal recessive manner. If 2 people without sickle-cell disease have a daughter who has this disease, what is the probability that their next child will be a boy with sickle-cell disease?

Question

Quizplus · Accepted Answer

Both parents must be carriers (heterozygous) for their daughter to have sickle-cell disease. The probability of having a child with the disease is 1/4, and the probability of having a boy is 1/2. Therefore, the probability of having a boy with sickle-cell disease is 1/4 * 1/2 = 1/8.

In Humans, Sickle-Cell Disease Is Due to a Defect in a Single