An Organism Acquires a Mutation in the Gene for Pyruvate

An organism acquires a mutation in the gene for pyruvate dehydrogenase that renders the protein unable to bind NADH. What is the most likely consequence of this mutation?

A) Fats will be oxidized at a higher rate than normal.
B) Pyruvate will not be able to enter the mitochondria.
C) Pyruvate oxidation will cease to occur.
D) ATP synthesis will proceed at a high rate even when the cell has an ample supply.
E) Substrate level phosphorylation will cease to occur.