Females are much more likely than males to develop conditions influenced by genes that are located on the X chromosome, because they have two X chromosomes instead of one and therefore twice as much opportunity to experience problems with genes on those chromosomes.

Question

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Females have two X chromosomes, but one of these is typically inactivated in each cell, which means they do not have twice the opportunity to experience problems with genes on those chromosomes. Additionally, having two X chromosomes often provides a protective effect against X-linked recessive disorders, as the presence of a normal allele on one X chromosome can mask the effect of a recessive mutation on the other.

Females Are Much More Likely Than Males to Develop Conditions