Simultaneous activation of climbing and parallel fibers results in _________ in Purkinje cells.
A)increases in EPSPs
B)decreases in EPSPs
C)increases in IPSPs
D)decreases in IPSPs

Question

Simultaneous activation of climbing and parallel fibers results in _________ in Purkinje cells.​ 
A)increases in EPSPs 
B)decreases in EPSPs 
C)increases in IPSPs 
D)decreases in IPSPs

Quizplus · Accepted Answer

Simultaneous activation of climbing and parallel fibers leads to a decrease in EPSPs in Purkinje cells due to the activation of the climbing fiber-induced long-term depression (CF-LTD) mechanism, which decreases the strength of the parallel fiber-Purkinje cell synapse.

Simultaneous Activation of Climbing and Parallel Fibers Results in _________