What Was the Major Difference Between Medina and Mecca

What was the major difference between Medina and Mecca?

A) Political dominance in Medina was contested between a number of Jewish and bedouin tribes.
B) Mecca was established in an oasis, and Medina was in a mountainous region.
C) Medina was engaged in long-distance caravan trade, while Mecca was not.
D) Medina was located on the western side of the Arabian peninsula, while Mecca was located on the Persian Gulf.