Depression or even death may result from Selye's stage of the general adaptation syndrome (GAS)that he called,

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Selye's stage of exhaustion in the general adaptation syndrome (GAS) is characterized by prolonged exposure to stressors that can lead to physical and emotional exhaustion, as well as an increased vulnerability to disease, depression, and even death. This stage occurs after the initial alarm stage and the subsequent stage of resistance.

Depression or Even Death May Result from Selye's Stage of the General