Most medications that improve mood in people with major depressive disorder act to suppress REM sleep.

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Many antidepressant medications, such as selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, and monoamine oxidase inhibitors, have been found to significantly suppress rapid eye movement (REM) sleep, which is when dreaming occurs. This is thought to be one way that these medications improve mood, as REM sleep disruption has been linked to depressive symptoms.

Most Medications That Improve Mood in People with Major Depressive