Homogentisic acid would accumulate under which of the following conditions?
A)a deficiency of p-hydroxyphenolypyruvate
B)defective enzyme 1
C)defective enzyme 2
D)a deficiency of 4-maleylacetoacetic acid

Question

Quizplus · Accepted Answer

Homogentisic acid is an intermediate in the catabolism of phenylalanine and tyrosine, and is converted to maleylacetoacetate by the enzyme homogentisate 1,2-dioxygenase. Defective enzyme 2 (homogentisate 1,2-dioxygenase) would lead to an accumulation of homogentisic acid.

Homogentisic Acid Would Accumulate Under Which of the Following Conditions