Cohesin holds sister chromatids together during the early part of mitosis. In anaphase, cohesin breaks down, allowing sister chromatids to separate. In meiosis, cohesin is protected at the centromeres during anaphase I, and so homologous chromosomes, but not sister chromatids, separate in meiosis I. The breakdown of centromeric cohesin allows sister chromatids to separate in anaphase II of meiosis.
-How does shugoshin affect sister chromatids in meiosis I and meiosis II?

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The Answer of Cohesin holds sister chromatids together during the early part of mitosis. In anaphase, cohesin breaks down, allowing sister chromatids to separate. In meiosis, cohesin is protected at the centromeres during anaphase I, and so homologous chromosomes, but not sister chromatids, separate in meiosis I. The breakdown of centromeric cohesin allows sister chromatids to separate in anaphase II of meiosis.
-How does shugoshin affect sister chromatids in meiosis I and meiosis II?

Cohesin Holds Sister Chromatids Together During the Early Part of Mitosis