The centromere is a region of the chromosome to which spindle fibers attach. Centromeres display considerable variation in structure and are distinguished by epigenetic alterations to chromatin stucture, including the use of a variant H3 histone in the nucleosome. In addition to their role in chromosome movement, centromeres help control the cell cycle by inhibiting anaphase until chromosomes are attached to spindle fibers from both poles.
-What happens to a chromosome that loses its centromere?
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