Which receptors for HIV would you expect to find on macrophages and T cells?
A)CCR5 and CD4 on macrophages;CXCR4 and CD4 on T cells
B)CCR5 and CXCR4 on macrophages;CD4 and CXCR4 on T cells
C)CD4 and CXCR4 on macrophages;CXCR4 and CD4 on T cells
D)CXCR4 and CD4 on macrophages;CCR5 and CD4 on T cells

Question

Quizplus · Accepted Answer

Macrophages are predominantly infected by HIV strains that use the chemokine receptor CCR5 as a co-receptor, along with the CD4 receptor, to enter the cell. T cells, on the other hand, can be infected by HIV strains that use either CCR5 or CXCR4 along with the CD4 receptor to enter the cell. Therefore, the receptors you would expect to find on macrophages are CCR5 and CD4, and on T cells are CXCR4 and CD4. This is the combination present in option A.

Which Receptors for HIV Would You Expect to Find on Macrophages