Which of the following drugs inhibits ergosterol synthesis, is important in treating Candida fungemias, and is used orally to suppress relapses of cryptococcal meningitis in AIDS patients?

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Fluconazole is an imidazole; all imidazoles inhibit ergosterol synthesis. Fluconazole has become the mainstay in the treatment of serious Candida infections, and it is used to prevent relapse of fungal CNS infections in compromised patients. Amphotericin B and nystatin both bind to ergosterol and create membrane pores, causing cell leakage and death. Echinocandins inhibit the fungal cell wall synthesis. Griseofulvin is not used against Candida as it may make the infection worse.

Which of the Following Drugs Inhibits Ergosterol Synthesis, Is Important