A 14-year-old girl has symptoms that include a low-grade fever, chills, headache, muscle aches, and malaise. A physical examination indicates an enlarged spleen. A Monospot test is negative. The laboratory finding that would confirm a diagnosis would be

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Symptoms are consistent with a mononucleosis disease that is usually caused by EBV or CMV. The lack of a positive Monospot test for heterophile antibodies and presence of "owl's eye" cells would indicate CMV.

A 14-Year-Old Girl Has Symptoms That Include a Low-Grade Fever