$beta-lactam$ drugs bind to penicillin-binding proteins to halt the synthesis of peptidoglycan. Where are these proteins located?

Question

Quizplus · Accepted Answer

The PBPs are actually in the cytoplasmic membrane, even though the substrate is the cell peptidoglycan. Thus, $\beta$-lactams must penetrate the Gram-negative outer membrane through the porins and cross the peptidoglycan to bind. In the Gram-positive bacteria, they just have to cross the peptidoglycan to bind in the membrane.

beta−lactambeta-lactambeta−lactam Drugs Bind to Penicillin-Binding Proteins to Halt the Synthesis of of Peptidoglycan

$beta-lactam$ Drugs Bind to Penicillin-Binding Proteins to Halt the Synthesis of of Peptidoglycan