A 28-year-old man compromised by chemotherapy now has a life-threatening meningitis caused by Histoplasma capsulatum. Which of the following antifungal drugs is fungicidal and appropriate for initial systemic use until the infection can be treated with maintenance therapy?

Question

Quizplus · Accepted Answer

Both amphotericin B (the correct answer) and nystatin are fungicidal, but nystatin is not used for systemic infections. Chloramphenicol is bactericidal. Ketoconazole and itraconazole are both fungistatic, and griseofulvin is not used systemically and localizes only in keratinized tissues.

A 28-Year-Old Man Compromised by Chemotherapy Now Has a Life-Threatening