A hospitalized burn patient develops toxic shock syndrome. An enterotoxin secreting Staphylococcus is isolated from the burn lesion. This superantigen acts by

Question

Quizplus · Accepted Answer

The superantigen produced by Staphylococcus simultaneously binds the T cell receptor and the MHC class II molecule regardless of the antigen occupying the antigenbinding groove. This cross-linking between an antigen presenting cell and a T cell leads to a broad spectrum activation of effector cells resulting in a large scale production of cytokines, often referred to as a "Cytokine Storm".

A Hospitalized Burn Patient Develops Toxic Shock Syndrome VβV\betaVβ Region on Multiple B Cells

A Hospitalized Burn Patient Develops Toxic Shock Syndrome $V\beta$ Region on Multiple B Cells