Which of the Following Is the Best Definition of Autoimmune

Which of the following is the best definition of autoimmune disease?

A) a condition in which B cells and T cells respond independently to antigens and do not interact correctly
B) a condition in which the acquired immune system fails to recognize the second infection by the same antigen
C) a condition in which a molecule belonging to the host is treated like an antigen and triggers an immune response
D) a condition in which the immune system creates random antibodies without being triggered by an antigen