You are doing experiments in cell culture with a novel inhibitor, of lipid metabolism. Your studies determine that in the presence of the inhibitor, the cells are unable to elicit a normal response to antigen addition to the culture. Which of the following lipid classes is likely to be reduced because of the addition of the inhibitor?

Question

Quizplus · Accepted Answer

Sphingolipids are important components of cell membranes and play a crucial role in cell signaling and immune responses. Inhibition of lipid metabolism affecting sphingolipids could impair the cell's ability to respond to antigens.  Platelet-activating factor (PAF) functions as a mediator of hypersensitivity, acute inflammatory reactions, and anaphylactic shock. PAF is a member of the plasmalogen family of lipid. PAF is synthesized in response to the formation of antigen-IgE complexes on the surfaces of basophils, neutrophils, eosinophils, macrophages, and monocytes. The inhibitor is most likely inhibiting the synthesis of PAF in these cells thus, the lack of appropriate response to antigen addition.

You Are Doing Experiments in Cell Culture with a Novel