You are treating a patient who complains of having an intense or uncontrollable thirst with a strong craving for ice water. The patient produces large amounts of urine (8-10 L per day). Additional symptoms include fatigue, headache, irritability, and muscle pains. Given the symptoms you suspect nephrogenic diabetes insipidus. If this diagnosis is correct, which of the following membrane transporter types would be defective in your patient?

Question

Quizplus · Accepted Answer

The Answer is A
EXPLANATION: Nephrogenic diabetes insipidus (NDI) is a disorder in which a defect in the tubules in the kidneys causes a person to pass a large amount of urine. This disorder is caused by an improper response of the kidney to antidiuretic hormone (ADH, also called vasopressin), leading to a decrease in the ability of the kidney to concentrate the urine by removing free water. The primary cause of NDI is a mutation in the ADH receptor in the kidney. However, NDI can also result from mutations in the aquaporin-2 gene.

You Are Treating a Patient Who Complains of Having an Intense