Which of the following is associated with increased glucose uptake due to its ability to prevent phosphorylation of downstream effectors of the insulin-signaling cascade?

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Quizplus · Accepted Answer

α-lipoic acid is known to enhance glucose uptake by improving insulin sensitivity and preventing the phosphorylation of downstream effectors in the insulin-signaling pathway.  Lipoic acid (LA) is an essential cofactor for the E2 component of α-ketoacid dehydrogenase complexes, exclusively located in mitochondria. These include the PDH, α-ketoglutarate dehydrogenase (KGDH), and branched chain α-ketoacid dehydrogenase (BCKDH) complexes. Extensive evidence suggests that LA may have therapeutic usefulness in lowering blood glucose levels in diabetic conditions and that the intracellular redox status plays a role in the modulation of insulin resistance. Lipoic acid has been shown to stimulate glucose uptake by affecting components of the insulin-signaling pathway

Which of the Following Is Associated with Increased Glucose Uptake