The activity of which of the following enzymes in the erythrocyte will be decreased in patients with a deficiency of thiamin?

Question

Quizplus · Accepted Answer

Thiamin (vitamin B1) is a cofactor for the enzyme transketolase, which is involved in the pentose phosphate pathway. A deficiency in thiamin would lead to decreased activity of transketolase in erythrocytes.  The pentose phosphate pathway (PPP) is a critical pathway of glucose oxidation within erythrocytes due to it being required for the generation of NADPH. The transketolase enzyme, involved in the nonoxidative reactions of the PPP, requires TPP as a cofactor

The Activity of Which of the Following Enzymes in the Erythrocyte