An individual with pernicious anemia has an inability to metabolize which of the following compounds?

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Pernicious anemia is caused by a deficiency in vitamin B12, which is necessary for the conversion of methylmalonyl-CoA to succinyl-CoA. Without vitamin B12, methylmalonyl-CoA cannot be properly metabolized. Pernicious anemia is one of many types of the larger family of megaloblastic anemias. It is caused by loss of secretion of intrinsic factor from the gut. Intrinsic factor is essential for subsequent absorption of vitamin B12 in the intestines. Vitamin vitamin B₁₂ is a critical coenzyme in the methionine synthase and methylmalonyl-CoA-mutase catalyzed reactions. Methylmalonyl-CoA mutase is involved in the conversion of propionyl-CoA to the TCA cycle intermediate, succinyl-CoA, specifically the reaction whereby methylmalonyl-CoA is converted to succinyl-CoA.

An Individual with Pernicious Anemia Has an Inability to Metabolize