A dietary deficiency of vitamin C would result in a decrease in which of the following?

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Quizplus · Accepted Answer

Vitamin C is essential for the hydroxylation of proline to hydroxyproline, a critical step in collagen synthesis. A deficiency in vitamin C impairs this conversion, leading to weakened collagen and connective tissue. The active form of vitamin C is ascorbic acid itself. The main function of ascorbate is as a reducing agent in a number of different reactions. Ascorbate is the cofactor for Cu+-dependent monooxygenases and Fe2+-dependent dioxygenases. Ascorbate has the potential to reduce cytochromes a and c of the respiratory chain as well as molecular oxygen. The most important reaction requiring ascorbate as a cofactor is the hydroxylation of proline residues in collagen. Vitamin C is, therefore, required for the maintenance of normal connective tissue as well as for wound healing since synthesis of connective tissue is the first event in wound tissue remodeling.

A Dietary Deficiency of Vitamin C Would Result in a Decrease