Drugs that inhibit enzymes in a competitive manner will have which of the following effects on the Michaelis-Menten equation derived parameters:V_max and/or K_m ?

Question

Quizplus · Accepted Answer

The Answer is D
EXPLANATION: Competitive inhibitors bind enzyme at the catalytic site, thereby competing with substrate for binding in a dynamic equilibrium-like process. This type of inhibition is reversible by the addition of higher concentrations of substrate. With competitive inhibitors the maximum velocity (V_max) of the reaction is unchanged, while the apparent affinity of the substrate to the binding site is decreased. In other words, K_m, as defined by the substrate concentration required for half maximal activity, is increased.

Drugs That Inhibit Enzymes in a Competitive Manner Will Have