You are studying the effects of compounds that inhibit the activity of succinate dehydrogenase, SDH. You demonstrate that malonate is a competitive inhibitor of this enzyme. Which of the following sets of findings would most likely provide ideal conditions for maximum inhibition of SDH by malonate?

Question

Quizplus · Accepted Answer

For maximum inhibition by a competitive inhibitor like malonate, the inhibitor concentration should be high relative to the substrate concentration. In option D, malonate is at a high concentration (10 mM) compared to succinate (1 mM), and the K_i is low (1 mM), indicating strong inhibition.

You Are Studying the Effects of Compounds That Inhibit the Activity