You are testing a novel fatty acid-related compound for it efficacy in the treatment of obesity. When the compound is added to the chow of laboratory animals, there is a significant reduction in food intake leading to a reduction on overall body weight. You discover that the compound can bind to and activate the G-protein-coupled receptor, GPR119. Your results indicate that your test compound most likely functions similarly to which of the following lipids?

Question

Quizplus · Accepted Answer

Oleoylethanolamide (OEA) is known to activate GPR119, leading to reduced food intake and weight loss, similar to the effects observed with the novel compound.  Oleoylethanolamide (OEA) is produced by mucosal cells in the proximal small intestine from dietary oleic acid. OEA has been shown to activate the fatty acid-sensing GPCR identified as GPR119. When OEA is administered to laboratory animals, the result is a significant reduction in food intake and body weight gain. These effects of OEA are the result of the activation of the nuclear receptor PPARα resulting in the observed modification of feeding behavior and motor activity in laboratory animals.

You Are Testing a Novel Fatty Acid-Related Compound for It