Excess Delivery of Free Fatty Acids to the Pancreas Results

Excess delivery of free fatty acids to the pancreas results in progressive damage to the b-cells as these fats are oxidized. The primary cause of this progressive damage is due to which of the following processes?

A) deficiency in peroxisomal oxidative capacity resulting in increased fat droplet production which results in apoptosis
B) excess accumulation of triglycerides derived from the fatty acids
C) increase in ER stress due to incorporation of the fats into membrane lipids triggering apoptosis
D) increased fat oxidation in the peroxisomes results in release of cytochrome c triggering apoptosis
E) limiting levels of catalase resulting in ROS excess leading to membrane lipid damage and mitochondrial dysfunction