The Hypercholesterolemia That Is Associated with Familial Hypercholesterolemia Is Due

The hypercholesterolemia that is associated with familial hypercholesterolemia is due to which of the following?

A) abnormally elevated production of LDL
B) abnormally elevated production of VLDL by the liver
C) abnormally reduced production of HDL, resulting in a diminished capacity of reverse cholesterol transport
D) defective LDL receptors leading to reduced uptake of plasma LDL and IDL
E) defective remnant receptors on hepatic cells, leading to reduced uptake of chylomicron remnants