Obesity is an epidemic in the United States and other industrialized countries, resulting in significant health consequences and expense. Therefore, discovering novel therapies for modifying food intake would have particular benefits to the treatment of obesity. Recent work has demonstrated that feeding behaviors are reduced following the consumption of fat through the actions of which of the following apolipoproteins?

Question

Quizplus · Accepted Answer

ApoA-IV is known to be involved in the regulation of feeding behavior and is associated with reduced food intake following fat consumption.  Apolipoprotein A-IV (apoA-IV) is synthesized exclusively in the small intestine and the hypothalamus. Intestinal synthesis of apoA-IV increases in response to ingestion and absorption of fat, and it is subsequently incorporated into chylomicrons and delivered to the circulation via the lymphatic system. Systemic apoA-IV has been shown to have effects in the CNS involving the sensation of satiety. Studies in laboratory animals have indicated that the effects exerted on appetite by apoA-IV may be due to direct hypothalamic synthesis and secretion. This is demonstrated by blocking apoA-IV actions via central injection of antibodies to the protein, which results in increased food consumption. Additional studies have shown that apoA-IV is involved in inhibiting food intake following the ingestion of fat.

Obesity Is an Epidemic in the United States and Other