Allopurinol is an inhibitor of xanthine oxidase. Administration of allopurinol to a patient with gout and normal HGPRT levels would be expected to lead to which of the following?

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Most forms of gout are the result of excess purine production and consequent catabolism or due to a partial deficiency in the salvage enzyme, HGPRT. Most forms of gout can be treated by administering the antimetabolite allopurinol that strongly inhibits xanthine oxidase. The substrates for xanthine oxidase are hypoxanthine and xanthine; therefore, inhibition of the enzyme results in increased levels of hypoxanthine and xanthine in the blood and urine.

Allopurinol Is an Inhibitor of Xanthine Oxidase