The gouty arthritis in patients with Lesch-Nyhan syndrome results from a genetic defect in which of the following enzymes?

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Lesch-Nyhan syndrome is caused by a deficiency in the enzyme hypoxanthine guanine phosphoribosyltransferase (HGPRT), leading to excessive uric acid production and gouty arthritis.  Lesch-Nyhan syndrome is a disorder related to defects in the activity of the purine nucleotide salvage enzyme, hypoxanthine-guanine phosphoribosyltransferase (HGPRT). The characteristic clinical features of the LNS are mental retardation, spastic cerebral palsy, choreoathetosis, uric acid urinary stones, and selfdestructive biting of fingers and lips. The uric acid overproduction and its associated consequences (eg, gouty arthritis) are the result of a block in purine nucleotide salvage, leading to increased catabolism to uric acid.

The Gouty Arthritis in Patients with Lesch-Nyhan Syndrome Results from a Genetic