You are studying the effects of a novel compound on the processes of protein synthesis using a cell culture system. You find that addition of your compound results in premature termination of protein synthesis. Analysis of the compound reveals that it has structural characteristics of an aminoacyltRNA. Which of the following protein-synthesis inhibitors is most similar to your test compound?

Question

Quizplus · Accepted Answer

Puromycin is an antibiotic that mimics aminoacyl-tRNA and causes premature termination of protein synthesis by incorporating itself into the growing polypeptide chain, similar to the effects observed with the novel compound.  Puromycin has a chemical structure that resembles an aminoacyl-tRNA and it interferes with peptide transfer resulting in premature termination in both prokaryotes and eukaryotes.

You Are Studying the Effects of a Novel Compound on the Processes