Agouti-related peptide (AgRP) is an orexigenic hormone that functions to increase the desire for food intake by antagonizing the actions of which of the following anorexigenic hormones?

Question

Quizplus · Accepted Answer

AgRP antagonizes the actions of α-MSH at the melanocortin receptors, which are involved in reducing food intake.  AgRP together with NPY represent a distinct set of ARC-expressed orexigenic peptides. AgRP is classically referred to as a member of the central melanocortin system, which in addition to AgRP comprises α-melanocyte stimulating hormone, α-MSH (see below for description of α-MSH actions) and 2 melanocortin receptors identified as melanocortin receptor 3 (MC3R) and melanocortin receptor 4 (MC4R). Whereas, α-MSH is an agonist of both MC3R and MC4R, AgRP serves to antagonize the actions of α-MSH at these same receptors with highest antagonist activity on MC4R.

Agouti-Related Peptide (AgRP) Is an Orexigenic Hormone That Functions to Increase