Maturity-onset diabetes in the young (MODY) is characterized by onset prior to age 25. A defect in which of the following genes is known to result in the specific form of MODY called MODY2?

Question

Quizplus · Accepted Answer

MODY2 is caused by mutations in the glucokinase gene, which plays a critical role in glucose sensing and regulation of insulin secretion.  All cases of MODY have shown impaired b-cell function. Patients may also exhibit insulin resistance and late b-cell failure. MODY2 results from defects in pancreatic glucokinase.

Maturity-Onset Diabetes in the Young (MODY) Is Characterized by Onset