Although the role of aPC in the termination of coagulation is extremely important, it also serves many additional functions that alter the inflammator processes occurring in the vasculature. The antiinflammatory functions of aPC are, in part, due to the activation of which of the following?

Question

Quizplus · Accepted Answer

Activated protein C (aPC) exerts its anti-inflammatory effects partly through the activation of protease activated receptor-1 (PAR-1). Activated PC binds to the endothelial protein C receptor (EPCR) and leads to the activation of PAR-1 which elicits cytoprotective and anti-inflammatory responses within endothelial cells. The cytoprotective effects elicited via aPC activation of PAR-1 include protection of the endothelial cell barrier and induction of antiapoptotic signaling pathways as well as expression of eNOS. Additional endothelial responses to aPC activation of PAR-1 occur via inhibition of the expression and actions of the potent pro-inflammatory transcription factor NFκB. The suppression of NFκB action results in downregulation of the synthesis of endothelial pro-inflammatory cytokines such as IL-6 and IL-8, the chemokine MCP-1 (monocyte chemoattractant protein-1), and the cell adhesion molecule ICAM-1 (intercellular adhesion molecule-1).

Although the Role of APC in the Termination of Coagulation