Which of the following represents a critical role of thrombin in the promotion of coagulation?

Question

Quizplus · Accepted Answer

Thrombin not only promotes the formation of a stable clot but its actions also lead to self-limiting of the extent of the coagulation process. The formation of a stable fibrin clot is a critical role of thrombin in the promotion of coagulation. Thrombinmediated release of the fibrinopeptides generates fibrin monomers that spontaneously aggregate in a regular array, forming a somewhat weak fibrin clot. In addition to fibrin activation, thrombin converts factor XIII to factor XIIIa, a highly specific transglutaminase that introduces cross-links composed of covalent bonds between the amide nitrogen of glutamines and e-amino group of lysines in the fibrin monomers forming a stable clot.

Which of the Following Represents a Critical Role of Thrombin