Which of the following is a characteristic of eukaryotic pyruvate dehydrogenase?
A)It is a complex of 2 enzymes.
B)It is structurally related to succinate dehydrogenase.
C)The active site is at the centre of the 96 subunits.
D)TPP is a required cofactor for E1.

Question

Quizplus · Accepted Answer

Eukaryotic pyruvate dehydrogenase requires thiamine pyrophosphate (TPP) as a cofactor for its E1 subunit. The enzyme is a complex of three enzymes, not two, and its active sites are located on the surface, not at the centre, of the complex. It is not structurally related to succinate dehydrogenase.

Which of the Following Is a Characteristic of Eukaryotic Pyruvate