Seven of the 10 reactions of glycolysis are reversible (DG near zero)and can be used in reverse of glycolysis for gluconeogenesis.Which enzymes catalyze the three irreversible reactions?

Question

Quizplus · Accepted Answer

The three irreversible reactions of glycolysis are catalyzed by hexokinase, phosphofructokinase-1, and pyruvate kinase. These reactions have a large negative change in free energy (DG) and cannot proceed in the reverse direction under normal cellular conditions. These enzymes are regulated to ensure that the flux of glycolysis proceeds primarily in the forward direction, while the enzymes of gluconeogenesis catalyze the reverse reactions to generate glucose from non-carbohydrate sources.

Seven of the 10 Reactions of Glycolysis Are Reversible (DG