Which enzyme carries out a reaction of the citric acid cycle with the largest negative ∆G value?

Question

Quizplus · Accepted Answer

Citrate synthase catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate, which is the first step of the citric acid cycle. This reaction has the largest negative ∆G value, indicating it is highly exergonic and thus, highly favorable under standard conditions. This step is also considered to be one of the rate-limiting steps of the cycle.

Which Enzyme Carries Out a Reaction of the Citric Acid